Biliary excretion

Construction of determination of cefditoren and the investigation of mechanism of biliary excretion

头孢妥仑测定方法的建立及胆汁排泄机制研究

Molecular Mechanism of Biliary Excretion of Cefditoren and the Effects of Cefditoren on the Expression Levels of Hepatic Transporters

头孢妥仑胆汁排泄的分子机制及其对肝脏转运蛋白调节作用的研究

Mathematical expression of the model for liver and biliary excretion

肝-胆排泄模型的数学表达

Biliary excretion of genistein and its metabolite at different doses in rats

不同剂量染料木黄酮及其代谢产物在大鼠胆汁中的排泄动力学

Conclusion Hepatic uptake and biliary excretion function is closely related to the severity of liver damage and cholestasis .

结论肝摄取和排泄功能与肝细胞损害和胆汁淤积程度密切相关；

Many researches indicate that CO generated by heme oxygenase controls the biliary excretion and increase in excretion of bile salts and phospholipids .

大量研究表明HO作用下产生的内源性的CO能调节肝胆汁分泌。

Biliary excretion was also an important route of excretion . Normal rats excreted 57.7 % of the administered radioactivity in the bile in 48 hours , while only 20.2 % was in unchanged form .

静注后48小时，自胆汁排泄剂量的57.7%，其中原形药放射性占剂量的20.2%。

The excretion of parent drug in urine amounted to only 0 09 % of the dosage and in feces to 42 9 % within 24 h after dosing . The biliary excretion were mainly metabolites and only 0 14 % of parent drug of the dosage within 12 h.

药后24h内尿和粪的排泄量分别占给药量的009%和429%，12h内胆汁排泄的主要为代谢产物，原型药物仅为给药量的014%。